GE Healthcare has extended its ReadyToProcess™ platform of ready-to-use systems with the launch of ReadyCircuit disposable flow path assemblies and ReadyKart, a mobile processing station for the quick setup of sterile fluid processing systems. All new products are used in the manufacture of biopharmaceuticals.
ReadyCircuit’s range of over 250 bags, sensors, filtration devices, tubing and sub-assemblies with aseptic connectors enable the user to configure and deploy an optimal bioprocess set-up within minutes. As standard, user configurable sub-assemblies, ReadyCircuit products permit single use processes to be deployed off the shelf instead of requiring weeks like conventional disposable bag sets. Custom assemblies built to user specifications are also available. The disposable ready-to-use format of ReadyCircuit eliminates the need for cleaning and cleaning validation, and thus contributes to reducing costs and enabling the development of biopharmaceuticals, such as vaccines and monoclonal antibodies, with lower capital investment. In addition, ReadyCircuit enables time between batches to be reduced, thereby increasing manufacturing agility.
Most assemblies use ReadyMate™ genderless aseptic disposable connectors for a simple, self-contained and robust connection, providing the flexibility that ensures users can setup their bioprocess with the required layout in the designated space. Unique to the portfolio are a series of pre-flushed validated sterile filtration modules (including TFF, MF and UF) that terminate in ReadyMate connectors making them ideal for aseptic processing or where terminal sterile filtration is not feasible.
The ReadyKart mobile processing station is a flexible cart for the quick configuration of a wide range of sterile and disposable fluid processing systems for product and process development or pilot manufacturing. The quick and convenient setup with disposable ReadyToProcess™ components saves time, and with its nesting capabilities, the carts can be combined, adding yet more flexibility.
Both ReadyCircuit and ReadyKart support the use of GE Healthcare’s ReadyToProcess equipment, which provides ready-to-use tools for all process stages, from fermentation, through to chromatography and filtration.
Here are few of GE’s ReadyToProcess™ products
The WAVE Bioreactor™ is a scalable, effective, cost-efficient rocking platform for cell culture. The culture medium and cells contact only a presterile, single-use CellbagTM ensuring very short setup times. There is no need for cleaning or sterilization, providing easy operation and protection against contamination. The rocking motion of the platform induces waves in the culture fluid to provide efficient mixing and gas transfer, resulting in an environment well-suited for cell growth. The Wave system is completely scaleable across our platform ranging from 200ml to 500l.
Truly Custom Bioreactors
Add a filter, quick connect fitting or 10 feet of tubing – you decide! Disposable bioreactors available in standard formats or easily customized to suit your specific cell culture process needs for research, development or cGMP manufacturing operations. Our Product Specialists will work with you to create your ideal cell culture bag for use with the WAVE Bioreactor System.
The cell contact surface is an FDA approved ethylene vinyl acetate (EVA) / low density polyethylene copolymer of the type routinely used for blood collection and handling of biological fluids. Outer layers are made of proprietary composites that provide exceptional strength and extremely low gas permeability.
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ReadyCircuit assemblies comprise bags, tubing, and connectors. Together with ReadyToProcess filters and sensors, ReadyCircuit assemblies form self-contained bioprocessing modules that maintain an aseptic path and provide convenience by removing time-consuming process steps associated with conventional systems.Bags, tube sets, filters and related equipment can be secured in appropriate orientations for efficient operation using the ReadyKart mobile processing station. With an array of features, and optional accessories, the ReadyKart is designed .
ReadyMate connectors are genderless aseptic connectors that allow simple connection of components maintaining secure workflows and sterile integrity. Additional accessories such as tube fuser and sealer of thermoplastic tubing support secure aseptic connectivity throughout the manufacturing process.
ReadyMate Disposable Aseptic Connector (DAC)
The ReadyMate DAC provides safe connections for high-fluid throughput and offers a secure, simple, and economical connection for upstream and downstream applications. ReadyMate DAC is autoclave and gamma compatible, and can be part of a sterile circuit.