Metabolomics is a post-genomic research field for analysis of low molecular weight compounds in biological systems, and its approaches offer an analysis of metabolite level changes in biological samples. Recently, metabolomic method has shown great potential in identifying new diagnostic markers and therapeutic targets for cancers. However, metabolomic studies on cancer metastasis remain scarce.
A research article published in the World Journal of Gastroenterology addresses this question. The authors used metabolomics, based on gas chromatography/mass spectrometry (GC/MS) technology, to study urinary metabolites expression changes among three mice groups.
This is the first report on urinary metabolomic investigation in gastric cancer using GC/MS. Biomarkers discovered in this study are mainly low molecular weight metabolites, which are difficult to detect by traditional methods. On the basis of this research, the authors believe that urinary metabolomic information investigated by GC/MS might play a significant role in early diagnosis and screening metastasis or recurrence of gastric cancer.
Source: Ye-Ru Wang
World Journal of Gastroenterology