Two separate controlled studies were performed. One compared a mixed population of uncultured rodent ADRCs, delivered immediately after extraction (fresh cells), to a control group>
Acute kidney injury was induced by occluding blood flow into and out of both kidneys for 38 minutes. Twenty minutes after reperfusion of the kidneys, 5 x 106 ADRCs or saline only were injected intra-arterially. All rodents were assessed daily for seven days for markers of kidney function (serum creatinine and blood urea nitrogen) and survival.
In the fresh ADRC arm, 100% of the treated group survived after seven days, compared to only 57% of the control group (p = 0.005). In the banked ADRC arm, 90% of the treated group survived after seven days, compared to 33% in the control group (p = 0.019).
The ADRC-treated subjects showed statistically significant improvements in kidney function, as measured by serum creatinine (p<0.0001 in fresh; p<0.05 in banked) and blood urea nitrogen levels (p<0.0001 in fresh, p<0.05 in banked).
In addition, substantial improvement in the histologic structure within the kidney was observed as measured by a reduction in tubular cell death and epithelial shedding (p<0.0001).
Source : Cytori Therapeutics